| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase TXK |
|---|
| Ligand | BDBM50212764 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_447354 (CHEMBL895282) |
|---|
| IC50 | 1400±n/a nM |
|---|
| Citation |  Snow, RJ; Abeywardane, A; Campbell, S; Lord, J; Kashem, MA; Khine, HH; King, J; Kowalski, JA; Pullen, SS; Roma, T; Roth, GP; Sarko, CR; Wilson, NS; Winters, MP; Wolak, JP; Cywin, CL Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors. Bioorg Med Chem Lett17:3660-5 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase TXK |
|---|
| Name: | Tyrosine-protein kinase TXK |
|---|
| Synonyms: | PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 61268.80 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P42681 |
|---|
| Residue: | 527 |
|---|
| Sequence: | MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
|
|
|
|---|
| BDBM50212764 |
|---|
| n/a |
|---|
| Name | BDBM50212764 |
|---|
| Synonyms: | CHEMBL233338 | N-(1-(3-aminopropyl)-5-(N-methylcyclohexanecarboxamido)-1H-benzo[d]imidazol-2-yl)thiophene-2-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H29N5O2S |
|---|
| Mol. Mass. | 439.574 |
|---|
| SMILES | CN(C(=O)C1CCCCC1)c1ccc2n(CCCN)c(NC(=O)c3cccs3)nc2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
