Ki Summary

Reaction Details

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Target

D(2) dopamine receptor

Ligand

BDBM50213520

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_438895 (CHEMBL889238)

85±n/a nM

Citation

Chiu, G; Li, S; Connolly, PJ; Pulito, V; Liu, J; Middleton, SA (Phenylpiperidinyl)cyclohexylsulfonamides: development of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS). Bioorg Med Chem Lett17:3930-4 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

D(2) dopamine receptor

Name:

D(2) dopamine receptor

Synonyms:

Type:

Cell-surface receptors

Mol. Mass.:

50647.10

Organism:

Homo sapiens (Human)

Description:

P14416

Residue:

443

Sequence:

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVS
REKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTA
SILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQN
ECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPL
KGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPP
SHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSR
RKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSA
VNPIIYTTFNIEFRKAFLKILHC

BDBM50213520

n/a

Name

BDBM50213520

Synonyms:

3-(difluoromethoxy)-N-((1s,4s)-4-(4-(2-(2,2,2-trifluoroethoxy)phenyl)piperidin-1-yl)cyclohexyl)benzenesulfonamide | CHEMBL228496

Type

Small organic molecule

Emp. Form.

C26H31F5N2O4S

Mol. Mass.

562.592

SMILES

FC(F)Oc1cccc(c1)S(=O)(=O)N[C@H]1CC[C@H](CC1)N1CCC(CC1)c1ccccc1OCC(F)(F)F |wU:17.21,14.14,(10.92,.29,;9.38,.29,;8.6,-1.03,;8.62,1.63,;7.08,1.64,;6.32,2.99,;4.76,2.99,;3.99,1.64,;4.75,.32,;6.32,.32,;3.98,-1.02,;2.66,-.26,;5.34,-1.8,;3.23,-2.33,;1.65,-2.33,;.89,-3.65,;-.63,-3.65,;-1.4,-2.3,;-.64,-.98,;.9,-1.02,;-2.97,-2.3,;-3.74,-3.62,;-5.27,-3.62,;-6.04,-2.28,;-5.27,-.95,;-3.73,-.98,;-7.59,-2.28,;-8.37,-3.62,;-9.91,-3.62,;-10.68,-2.27,;-9.89,-.95,;-8.37,-.95,;-7.59,.4,;-8.37,1.73,;-7.6,3.07,;-6.84,4.41,;-6.26,2.3,;-8.94,3.83,)|

Structure