Reaction Details |
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Target | Gonadotropin-releasing hormone receptor |
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Ligand | BDBM50213660 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_447478 (CHEMBL896501) |
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IC50 | 63±n/a nM |
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Citation | Chen, M; Guo, Z; Lanier, MC; Zhao, L; Betz, SF; Huang, CQ; Loweth, CJ; Ashweek, NJ; Liu, XJ; Struthers, RS; Bradbury, MJ; Behan, JW; Wen, J; O'Brien, Z; Saunders, J; Zhu, YF Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists. Bioorg Med Chem Lett17:3845-50 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gonadotropin-releasing hormone receptor |
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Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
Type: | Enzyme |
Mol. Mass.: | 37749.45 |
Organism: | Homo sapiens (Human) |
Description: | P30968 |
Residue: | 328 |
Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50213660 |
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n/a |
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Name | BDBM50213660 |
Synonyms: | (S)-1-(3-(1-(2-(4-(1H-tetrazol-5-yl)phenoxy)ethylamino)propan-2-yl)-2-(3,5-dimethylphenyl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-5(4H)-yl)-2-(2-fluoro-6-(trifluoromethyl)phenyl)ethanone | CHEMBL394634 |
Type | Small organic molecule |
Emp. Form. | C36H37F4N7O2 |
Mol. Mass. | 675.7183 |
SMILES | C[C@H](CNCCOc1ccc(cc1)-c1nnn[nH]1)c1c2CN(CCc2[nH]c1-c1cc(C)cc(C)c1)C(=O)Cc1c(F)cccc1C(F)(F)F |
Structure |
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