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TargetGonadotropin-releasing hormone receptor
LigandBDBM50213650
Substrate/Competitorn/a
Meas. Tech.ChEMBL_447479
Ki 1.5±n/a nM
Citation Chen MGuo ZLanier MCZhao LBetz SFHuang CQLoweth CJAshweek NJLiu XJStruthers RSBradbury MJBehan JWWen JO'Brien ZSaunders JZhu YF Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists. Bioorg Med Chem Lett 17:3845-50 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gonadotropin-releasing hormone receptor
Name:Gonadotropin-releasing hormone receptor
Synonyms:GnRH receptor | GnRH-R
Type:PROTEIN
Mol. Mass.:37767.60
Organism:Rattus norvegicus
Description:ChEMBL_1335047
Residue:327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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  Blast E-value cutoff:
BDBM50213650
n/a
NameBDBM50213650
Synonyms:CHEMBL233341 | adamantan-1-yl-{2-(3,5-dimethyl-phenyl)-3-[(S)-1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-5-yl}-methanone
TypeSmall organic molecule
Emp. Form.C36H46N4O
Mol. Mass.550.7766
SMILESC[C@H](CNCCc1ccncc1)c1c2CN(CCc2[nH]c1-c1cc(C)cc(C)c1)C(=O)C12CC3CC(CC(C3)C1)C2 |TLB:40:31:38:34.35.36,THB:40:35:38:31.32.39,29:31:38:34.35.36,39:31:34:38.37.36,39:37:34:40.31.32|
Structure
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