Reaction Details |
| Report a problem with these data |
Target | Purine nucleoside phosphorylase |
---|
Ligand | BDBM50214705 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_447605 (CHEMBL896619) |
---|
Ki | 2.7±n/a nM |
---|
Citation | Hikishima, S; Hashimoto, M; Magnowska, L; Bzowska, A; Yokomatsu, T Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP. Bioorg Med Chem Lett17:4173-7 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Purine nucleoside phosphorylase |
---|
Name: | Purine nucleoside phosphorylase |
Synonyms: | Inosine phosphorylase | NP | PNP | PNPH_BOVIN | Purine Nucleoside Phosphorylase (PNP) | Purine nucleoside phosphorylase |
Type: | Enzyme |
Mol. Mass.: | 32035.18 |
Organism: | Bos taurus (bovine) |
Description: | n/a |
Residue: | 289 |
Sequence: | MANGYTYEDYQDTAKWLLSHTEQRPQVAVICGSGLGGLVNKLTQAQTFDYSEIPNFPEST
VPGHAGRLVFGILNGRACVMMQGRFHMYEGYPFWKVTFPVRVFRLLGVETLVVTNAAGGL
NPNFEVGDIMLIRDHINLPGFSGENPLRGPNEERFGVRFPAMSDAYDRDMRQKAHSTWKQ
MGEQRELQEGTYVMLGGPNFETVAECRLLRNLGADAVGMSTVPEVIVARHCGLRVFGFSL
ITNKVIMDYESQGKANHEEVLEAGKQAAQKLEQFVSLLMASIPVSGHTG
|
|
|
BDBM50214705 |
---|
n/a |
---|
Name | BDBM50214705 |
Synonyms: | 5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1,1-difluoropentylphosphonate | 9-(5',5'-difluoro-5'-phosphonopentyl)guanine | 9-(5,5-DIFLUORO-5-PHOSPHONOPENTYL)GUANINE | CHEMBL236708 | [5-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-1,1-difluoro-pentyl]-phosphonic acid |
Type | Small organic molecule |
Emp. Form. | C10H14F2N5O4P |
Mol. Mass. | 337.2198 |
SMILES | Nc1nc2n(CCCCC(F)(F)P(O)(O)=O)cnc2c(=O)[nH]1 |
Structure |
|