| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50215009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_456402 (CHEMBL907491) |
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| IC50 | 94±n/a nM |
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| Citation |  Siliphaivanh, P; Harrington, P; Witter, DJ; Otte, K; Tempest, P; Kattar, S; Kral, AM; Fleming, JC; Deshmukh, SV; Harsch, A; Secrist, PJ; Miller, TA Design of novel histone deacetylase inhibitors. Bioorg Med Chem Lett17:4619-24 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50215009 |
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| n/a |
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| Name | BDBM50215009 |
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| Synonyms: | CHEMBL251757 | N-(2-aminophenyl)-4-(2-hydroxy-1,3-dioxo-1,3-bis(phenylamino)propan-2-yl)benzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H24N4O4 |
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| Mol. Mass. | 480.5146 |
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| SMILES | Nc1ccccc1NC(=O)c1ccc(cc1)C(O)(C(=O)Nc1ccccc1)C(=O)Nc1ccccc1 |
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| Structure | 
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