| Reaction Details |
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 | Report a problem with these data |
| Target | MAP kinase-activated protein kinase 3 |
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| Ligand | BDBM50215497 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_456524 (CHEMBL922890) |
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| IC50 | 160000±n/a nM |
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| Citation |  Trujillo, JI; Meyers, MJ; Anderson, DR; Hegde, S; Mahoney, MW; Vernier, WF; Buchler, IP; Wu, KK; Yang, S; Yang, S; Hartmann, SJ; Reitz, DB Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett17:4657-63 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| MAP kinase-activated protein kinase 3 |
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| Name: | MAP kinase-activated protein kinase 3 |
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| Synonyms: | 3pK | Chromosome 3p kinase | MAP kinase-activated protein kinase 3 (MAPKAP-K3) | MAPK-Activated Protein Kinase 3 (MK3) | MAPK-activated protein kinase 3 | MAPK3_HUMAN | MAPKAP kinase 3 | MAPKAPK-3 | MAPKAPK3 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 42991.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant MAPKAPK3 was phosphorylated by incubation with active p38alpha before assays. |
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| Residue: | 382 |
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| Sequence: | MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
LLNKRRKKQAGSSSASQGCNNQ
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| BDBM50215497 |
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| n/a |
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| Name | BDBM50215497 |
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| Synonyms: | 5-methoxy-9,12-diazatetracyclo[10.3.1.0^{2,10}.0^{3,8}]hexadeca-2(10),3,5,7-tetraene-11-carboxylic acid | CHEMBL394124 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18N2O3 |
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| Mol. Mass. | 286.3257 |
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| SMILES | COc1ccc2[nH]c3C(N4CCCC(C4)c3c2c1)C(O)=O |w:13.13,8.21,TEB:18:8:14:12.11.10| |
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| Structure | 
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