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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Androgen receptor | ||
| Ligand | BDBM18173 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_447721 (CHEMBL896729) | ||
| EC50 | 0.44±n/a nM | ||
| Citation |  Manfredi, MC; Bi, Y; Nirschl, AA; Sutton, JC; Seethala, R; Golla, R; Beehler, BC; Sleph, PG; Grover, GJ; Ostrowski, J; Hamann, LG Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators. Bioorg Med Chem Lett17:4487-90 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Androgen receptor | |||
| Name: | Androgen receptor | ||
| Synonyms: | ANDR_MOUSE | Ar | Nr3c4 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 98196.62 | ||
| Organism: | Mus musculus | ||
| Description: | ChEMBL_945930 | ||
| Residue: | 899 | ||
| Sequence: |
| ||
| BDBM18173 | |||
| n/a | |||
| Name | BDBM18173 | ||
| Synonyms: | 4-[(7R,7aS)-7-hydroxy-1,3-dioxo-hexahydro-1H-pyrrolo[1,2-a]imidazolidin-2-yl]-2-chloro-3-methylbenzonitrile | BMS-564929 | CHEMBL229264 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C14H12ClN3O3 | ||
| Mol. Mass. | 305.716 | ||
| SMILES | Cc1c(Cl)c(ccc1-n1c(O)c2[C@H](O)CCn2c1=O)C#N |r,wU:12.13,(.01,.36,;.81,1.67,;2.35,1.63,;3.09,.28,;3.16,2.94,;2.42,4.3,;.88,4.34,;.08,3.02,;-1.46,3.02,;-1.94,4.49,;-1.03,5.73,;-3.48,4.49,;-4.72,5.39,;-4.72,6.93,;-5.97,4.49,;-5.5,3.02,;-3.95,3.02,;-2.71,2.12,;-2.71,.58,;4.7,2.9,;6.24,2.9,)| | ||
| Structure | 
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