| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor X |
|---|
| Ligand | BDBM50216181 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_447773 (CHEMBL896782) |
|---|
| IC50 | 100000±n/a nM |
|---|
| Citation |  Hay, BA; Abrams, B; Zumbrunn, AY; Valentine, JJ; Warren, LC; Petras, SF; Shelly, LD; Xia, A; Varghese, AH; Hawkins, JL; Van Camp, JA; Robbins, MD; Landschulz, K; Harwood, HJ Aminopyrrolidineamide inhibitors of site-1 protease. Bioorg Med Chem Lett17:4411-4 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor X |
|---|
| Name: | Coagulation factor X |
|---|
| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54726.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 488 |
|---|
| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
|
|
|
|---|
| BDBM50216181 |
|---|
| n/a |
|---|
| Name | BDBM50216181 |
|---|
| Synonyms: | (R)-N-(2-methoxyphenethyl)-4-((diethylamino)methyl)-N-(pyrrolidin-3-yl)benzamide | CHEMBL233611 | PF-429242 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H35N3O2 |
|---|
| Mol. Mass. | 409.5643 |
|---|
| SMILES | CCN(CC)Cc1ccc(cc1)C(=O)N(CCc1ccccc1OC)[C@@H]1CCNC1 |
|---|
| Structure | 
|
|---|
Search and Browse
