| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 7 |
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| Ligand | BDBM50216378 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_440099 (CHEMBL890410) |
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| IC50 | >1000±n/a nM |
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| Citation |  Romagnoli, R; Baraldi, PG; Carrion, MD; Cara, CL; Preti, D; Cruz-Lopez, O; Tabrizi, MA; Moorman, AR; Gessi, S; Fogli, E; Sacchetto, V; Borea, PA From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor. J Med Chem50:3706-15 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 7 |
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| Name: | P2X purinoceptor 7 |
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| Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 68602.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99572 |
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| Residue: | 595 |
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| Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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| BDBM50216378 |
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| n/a |
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| Name | BDBM50216378 |
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| Synonyms: | CHEMBL231540 | isoquinolinesulfon-5-yl-[2-oxo-2-(4-o-tolylpiperazin-1-yl)ethyl]amide |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O3S |
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| Mol. Mass. | 424.516 |
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| SMILES | Cc1ccccc1N1CCN(CC1)C(=O)CNS(=O)(=O)c1cccc2cnccc12 |
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| Structure | 
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