| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50217123 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_448557 (CHEMBL897706) |
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| IC50 | 70±n/a nM |
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| Citation |  Castilho, MS; Guido, RV; Andricopulo, AD 2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors. Bioorg Med Chem15:6242-52 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50217123 |
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| n/a |
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| Name | BDBM50217123 |
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| Synonyms: | 3-((3-(3,5-dimethylphenoxy)benzyl)(3-phenoxyphenyl)amino)-1,1,1-trifluoropropan-2-ol | CHEMBL235525 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28F3NO3 |
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| Mol. Mass. | 507.5434 |
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| SMILES | Cc1cc(C)cc(Oc2cccc(CN(CC(O)C(F)(F)F)c3cccc(Oc4ccccc4)c3)c2)c1 |w:16.16| |
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| Structure | 
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