| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50128171 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_448557 (CHEMBL897706) |
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| IC50 | 400±n/a nM |
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| Citation |  Castilho, MS; Guido, RV; Andricopulo, AD 2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors. Bioorg Med Chem15:6242-52 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50128171 |
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| n/a |
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| Name | BDBM50128171 |
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| Synonyms: | 1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-[3-(4-trifluoromethoxy-phenoxy)-phenyl]-amino}-propan-2-ol | 1,1,1-trifluoro-3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-(trifluoromethoxy)phenoxy)phenyl)amino)propan-2-ol | 3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(4-(trifluoromethoxy)phenoxy)phenyl)amino)-1,1,1-trifluoropropan-2-ol | CHEMBL431366 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19F10NO4 |
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| Mol. Mass. | 587.4067 |
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| SMILES | OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2ccc(OC(F)(F)F)cc2)c1)C(F)(F)F |
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| Structure | 
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