| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50217579 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_448653 (CHEMBL897804) |
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| Ki | 6±n/a nM |
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| Citation |  Letavic, MA; Stocking, EM; Barbier, AJ; Bonaventure, P; Boggs, JD; Lord, B; Miller, KL; Wilson, SJ; Carruthers, NI Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors. Bioorg Med Chem Lett17:4799-803 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50217579 |
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| n/a |
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| Name | BDBM50217579 |
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| Synonyms: | (5-(4-(4-fluoropiperidin-1-yl)but-1-ynyl)-2-(4-(methylthio)phenoxy)phenyl)-N-methylmethanamine | CHEMBL391074 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29FN2OS |
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| Mol. Mass. | 412.563 |
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| SMILES | CNCc1cc(ccc1Oc1ccc(SC)cc1)C#CCCN1CCC(F)CC1 |
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| Structure | 
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