Reaction Details |
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Target | Coagulation factor X |
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Ligand | BDBM50218293 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_448736 (CHEMBL897883) |
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Ki | 18±n/a nM |
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Citation | Qiao, JX; Wang, TC; Wang, GZ; Cheney, DL; He, K; Rendina, AR; Xin, B; Luettgen, JM; Knabb, RM; Wexler, RR; Lam, PY Enantiopure five-membered cyclicdiamine derivatives as potent and selective inhibitors of factor Xa. Improving in vitro metabolic stability via core modifications. Bioorg Med Chem Lett17:5041-8 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor X |
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Name: | Coagulation factor X |
Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
Type: | Enzyme |
Mol. Mass.: | 54726.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 488 |
Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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BDBM50218293 |
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n/a |
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Name | BDBM50218293 |
Synonyms: | 3-chloro-N-((3R,4S)-4-(4-(2-oxopyridin-1(2H)-yl)benzamido)pyrrolidin-3-yl)-1H-indole-6-carboxamide | CHEMBL237923 |
Type | Small organic molecule |
Emp. Form. | C25H22ClN5O3 |
Mol. Mass. | 475.927 |
SMILES | Clc1c[nH]c2cc(ccc12)C(=O)N[C@@H]1CNC[C@@H]1NC(=O)c1ccc(cc1)-n1ccccc1=O |
Structure |
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