| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lyn |
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| Ligand | BDBM50218682 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_444954 (CHEMBL894104) |
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| IC50 | 230±n/a nM |
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| Citation |  Goldberg, DR; Hao, MH; Qian, KC; Swinamer, AD; Gao, DA; Xiong, Z; Sarko, C; Berry, A; Lord, J; Magolda, RL; Fadra, T; Kroe, RR; Kukulka, A; Madwed, JB; Martin, L; Pargellis, C; Skow, D; Song, JJ; Tan, Z; Torcellini, CA; Zimmitti, CS; Yee, NK; Moss, N Discovery and optimization of p38 inhibitors via computer-assisted drug design. J Med Chem50:4016-26 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lyn |
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| Name: | Tyrosine-protein kinase Lyn |
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| Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
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| Type: | Protein |
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| Mol. Mass.: | 58575.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07948 |
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| Residue: | 512 |
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| Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
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| BDBM50218682 |
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| n/a |
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| Name | BDBM50218682 |
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| Synonyms: | CHEMBL243575 | N-[2-(5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenylcarbamoyl)-benzo[b]thiophen-7-yl]-6-cyclopropylamino-nicotinamide |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33N5O5S2 |
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| Mol. Mass. | 607.744 |
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| SMILES | COc1c(NC(=O)c2cc3cccc(NC(=O)c4ccc(NC5CC5)nc4)c3s2)cc(cc1NS(C)(=O)=O)C(C)(C)C |
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| Structure | 
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