Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM50219241 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_437417 (CHEMBL906815) |
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IC50 | 2450±n/a nM |
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Citation | Kwon, YE; Park, JY; No, KT; Shin, JH; Lee, SK; Eun, JS; Yang, JH; Shin, TY; Kim, DK; Chae, BS; Leem, JY; Kim, KH Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics. Bioorg Med Chem15:6596-607 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache |
Type: | Enzyme |
Mol. Mass.: | 71812.79 |
Organism: | Electrophorus electricus (Electric eel) |
Description: | n/a |
Residue: | 633 |
Sequence: | MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFA
EPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLY
LNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGF
LALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDS
RPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLI
DQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYG
APGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIV
GDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHR
ASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINV
DGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAE
RQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
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BDBM50219241 |
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n/a |
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Name | BDBM50219241 |
Synonyms: | 4-[4-(benzhydryloxy)piperidino]butyl-N-(4-fluorophenyl)carbamate | CHEMBL426915 |
Type | Small organic molecule |
Emp. Form. | C29H33FN2O3 |
Mol. Mass. | 476.5823 |
SMILES | Fc1ccc(NC(=O)OCCCCN2CCC(CC2)OC(c2ccccc2)c2ccccc2)cc1 |
Structure |
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