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TargetTyrosine-protein phosphatase non-receptor type 2
LigandBDBM50219569
Substrate/Competitorn/a
Meas. Tech.ChEMBL_445833
Ki 9±n/a nM
Citation Wilson DPWan ZKXu WXKirincich SJFollows BCJoseph-McCarthy DForeman KMoretto AWu JZhu MBinnun EZhang YLTam MErbe DVTobin JXu XLeung LShilling ATam SYMansour TSLee J Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J Med Chem 50:4681-98 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein phosphatase non-receptor type 2
Name:Tyrosine-protein phosphatase non-receptor type 2
Synonyms:T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:Protein
Mol. Mass.:48481.80
Organism:Homo sapiens (Human)
Description:P17706
Residue:415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
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  Blast E-value cutoff:
BDBM50219569
n/a
NameBDBM50219569
Synonyms:4-bromo-3-carboxymethoxy-5-(3-{[1-(2,6-dimethylphenylcarbamoyl)piperidin-4-ylmethyl]amino}phenyl)thiophene-2-carboxylic acid | CHEMBL243268
TypeSmall organic molecule
Emp. Form.C28H30BrN3O6S
Mol. Mass.616.523
SMILESCc1cccc(C)c1NC(=O)N1CCC(CNc2cccc(c2)-c2sc(C(O)=O)c(OCC(O)=O)c2Br)CC1
Structure
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