Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetTyrosine-protein phosphatase non-receptor type 2
LigandBDBM50219583
Substrate/Competitorn/a
Meas. Tech.ChEMBL_445833
Ki 12±n/a nM
Citation Wilson DPWan ZKXu WXKirincich SJFollows BCJoseph-McCarthy DForeman KMoretto AWu JZhu MBinnun EZhang YLTam MErbe DVTobin JXu XLeung LShilling ATam SYMansour TSLee J Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site. J Med Chem 50:4681-98 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein phosphatase non-receptor type 2
Name:Tyrosine-protein phosphatase non-receptor type 2
Synonyms:T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:Protein
Mol. Mass.:48481.80
Organism:Homo sapiens (Human)
Description:P17706
Residue:415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVK
LQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKES
VKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTW
PDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGD
DINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPA
FDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKAT
TAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50219583
n/a
NameBDBM50219583
Synonyms:4-bromo-3-(carboxymethoxy)-5-[3-({1-[(2-{[(ethylamino)-carbonyl]amino}benzyl)sulfonyl]piperidin-4-yl}amino)phenyl]-thiophene-2-carboxylic acid | CHEMBL397903
TypeSmall organic molecule
Emp. Form.C28H31BrN4O8S2
Mol. Mass.695.602
SMILESCCNC(=O)Nc1ccccc1CS(=O)(=O)N1CCC(CC1)Nc1cccc(c1)-c1sc(C(O)=O)c(OCC(O)=O)c1Br
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: