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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | D(3) dopamine receptor | ||
| Ligand | BDBM50219934 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_449063 (CHEMBL898268) | ||
| IC50 | 3.8±n/a nM | ||
| Citation |  Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett17:5340-4 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| D(3) dopamine receptor | |||
| Name: | D(3) dopamine receptor | ||
| Synonyms: | DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 49540.58 | ||
| Organism: | Rattus norvegicus (Rat) | ||
| Description: | P19020 | ||
| Residue: | 446 | ||
| Sequence: |
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| BDBM50219934 | |||
| n/a | |||
| Name | BDBM50219934 | ||
| Synonyms: | CHEMBL399833 | N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)benzyl)piperidin-1-yl)ethyl)cyclohexyl)-4-chlorobenzenesulfonamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H34ClF3N2O2S | ||
| Mol. Mass. | 543.084 | ||
| SMILES | FC(F)(F)c1cccc(CC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(Cl)cc3)CC2)c1 |wU:19.22,wD:16.15,(43.36,5.75,;42.04,4.97,;42.81,3.63,;41.26,6.29,;40.7,4.2,;40.7,2.65,;39.37,1.88,;38.03,2.66,;38.05,4.2,;36.72,4.97,;35.38,4.21,;35.37,2.67,;34.05,1.9,;32.71,2.67,;31.38,1.9,;30.05,2.67,;28.71,1.9,;27.37,2.67,;26.04,1.9,;26.04,.36,;27.37,-.41,;28.71,.36,;24.69,-.44,;23.34,.32,;22.58,-1.01,;24.09,1.66,;22,1.09,;22.01,2.64,;20.67,3.42,;19.33,2.65,;18,3.41,;19.33,1.09,;20.67,.32,;32.71,4.21,;34.05,4.97,;39.37,4.96,)| | ||
| Structure | 
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