Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50220229 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_449159 (CHEMBL899424) |
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IC50 | 529±n/a nM |
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Citation | Hamblett, CL; Methot, JL; Mampreian, DM; Sloman, DL; Stanton, MG; Kral, AM; Fleming, JC; Cruz, JC; Chenard, M; Ozerova, N; Hitz, AM; Wang, H; Deshmukh, SV; Nazef, N; Harsch, A; Hughes, B; Dahlberg, WK; Szewczak, AA; Middleton, RE; Mosley, RT; Secrist, JP; Miller, TA The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. Bioorg Med Chem Lett17:5300-9 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50220229 |
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n/a |
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Name | BDBM50220229 |
Synonyms: | CHEMBL392644 | N-(2-aminophenyl)-6-(3,3-dimethylpiperazin-1-yl)nicotinamide |
Type | Small organic molecule |
Emp. Form. | C18H23N5O |
Mol. Mass. | 325.4081 |
SMILES | CC1(C)CN(CCN1)c1ccc(cn1)C(=O)Nc1ccccc1N |
Structure |
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