Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50223485 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_458175 (CHEMBL924433) |
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IC50 | 2±n/a nM |
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Citation | Garbaccio, RM; Huang, S; Tasber, ES; Fraley, ME; Yan, Y; Munshi, S; Ikuta, M; Kuo, L; Kreatsoulas, C; Stirdivant, S; Drakas, B; Rickert, K; Walsh, ES; Hamilton, KA; Buser, CA; Hardwick, J; Mao, X; Beck, SC; Abrams, MT; Tao, W; Lobell, R; Sepp-Lorenzino, L; Hartman, GD Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase. Bioorg Med Chem Lett17:6280-5 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50223485 |
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n/a |
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Name | BDBM50223485 |
Synonyms: | 6-(3-aminopropyl)-N-(2-(dimethylamino)ethyl)-1-oxo-1,2-dihydrobenzo[h]isoquinoline-9-carboxamide | CHEMBL249238 |
Type | Small organic molecule |
Emp. Form. | C21H26N4O2 |
Mol. Mass. | 366.4567 |
SMILES | CN(C)CCNC(=O)c1ccc2c(CCCN)cc3cc[nH]c(=O)c3c2c1 |
Structure |
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