Reaction Details |
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Target | Muscarinic acetylcholine receptor M2 |
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Ligand | BDBM50223990 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_450372 (CHEMBL900655) |
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IC50 | 12.5±n/a nM |
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Citation | Lainé, DI; Xie, H; Buffet, N; Foley, JJ; Buckley, P; Webb, EF; Widdowson, KL; Palovich, MR; Belmonte, KE Discovery of novel 8-azoniabicyclo[3.2.1]octane carbamates as muscarinic acetylcholine receptor antagonists. Bioorg Med Chem Lett17:6066-9 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M2 |
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Name: | Muscarinic acetylcholine receptor M2 |
Synonyms: | ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2 |
Type: | GPCR |
Mol. Mass.: | 51730.61 |
Organism: | Homo sapiens (Human) |
Description: | P08172 |
Residue: | 466 |
Sequence: | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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BDBM50223990 |
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n/a |
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Name | BDBM50223990 |
Synonyms: | 8,8-dimethyl-3-(phenyl-thiophen-2-ylmethyl-carbamoyloxy)-8-azonia-bicyclo[3.2.1]octane; bromide | CHEMBL237093 |
Type | Small organic molecule |
Emp. Form. | C21H27N2O2S |
Mol. Mass. | 371.516 |
SMILES | C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1cccs1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| |
Structure |
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