Compile Data Set for Download or QSAR

Found 209 hits with Last Name = 'buckley' and Initial = 'p'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223976 (8,8-dimethyl-3-(thiophen-3-yl-thiophen-3-ylmethyl-...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccsc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C19H25N2O2S2/c1-21(2)16-3-4-17(21)10-18(9-16)23-19(22)20(15-6-8-25-13-15)11-14-5-7-24-12-14/h5-8,12-13,16-18H,3-4,9-11H2,1-2H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223976 (8,8-dimethyl-3-(thiophen-3-yl-thiophen-3-ylmethyl-...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccsc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C19H25N2O2S2/c1-21(2)16-3-4-17(21)10-18(9-16)23-19(22)20(15-6-8-25-13-15)11-14-5-7-24-12-14/h5-8,12-13,16-18H,3-4,9-11H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223964 (3-(benzyl-thiophen-3-yl-carbamoyloxy)-8,8-dimethyl...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1ccsc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)18-8-9-19(23)13-20(12-18)25-21(24)22(17-10-11-26-15-17)14-16-6-4-3-5-7-16/h3-7,10-11,15,18-20H,8-9,12-14H2,1-2H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223964 (3-(benzyl-thiophen-3-yl-carbamoyloxy)-8,8-dimethyl...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1ccsc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)18-8-9-19(23)13-20(12-18)25-21(24)22(17-10-11-26-15-17)14-16-6-4-3-5-7-16/h3-7,10-11,15,18-20H,8-9,12-14H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223990 (8,8-dimethyl-3-(phenyl-thiophen-2-ylmethyl-carbamo...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1cccs1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)17-10-11-18(23)14-19(13-17)25-21(24)22(15-20-9-6-12-26-20)16-7-4-3-5-8-16/h3-9,12,17-19H,10-11,13-15H2,1-2H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223990 (8,8-dimethyl-3-(phenyl-thiophen-2-ylmethyl-carbamo...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1cccs1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)17-10-11-18(23)14-19(13-17)25-21(24)22(15-20-9-6-12-26-20)16-7-4-3-5-8-16/h3-9,12,17-19H,10-11,13-15H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223981 (8,8-dimethyl-3-(phenyl-thiophen-3-ylmethyl-carbamo...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)18-8-9-19(23)13-20(12-18)25-21(24)22(14-16-10-11-26-15-16)17-6-4-3-5-7-17/h3-7,10-11,15,18-20H,8-9,12-14H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223991 (3-(benzyl-thiophen-2-yl-carbamoyloxy)-8,8-dimethyl...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1cccs1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)17-10-11-18(23)14-19(13-17)25-21(24)22(20-9-6-12-26-20)15-16-7-4-3-5-8-16/h3-9,12,17-19H,10-11,13-15H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223981 (8,8-dimethyl-3-(phenyl-thiophen-3-ylmethyl-carbamo...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)18-8-9-19(23)13-20(12-18)25-21(24)22(14-16-10-11-26-15-16)17-6-4-3-5-7-17/h3-7,10-11,15,18-20H,8-9,12-14H2,1-2H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223991 (3-(benzyl-thiophen-2-yl-carbamoyloxy)-8,8-dimethyl...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1cccs1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)17-10-11-18(23)14-19(13-17)25-21(24)22(20-9-6-12-26-20)15-16-7-4-3-5-8-16/h3-9,12,17-19H,10-11,13-15H2,1-2H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223993 (8,8-dimethyl-3-[(3-methyl-thiophen-2-ylmethyl)-phe...) Show SMILES Cc1ccsc1CN(C(=O)OC1CC2CCC(C1)[N+]2(C)C)c1ccccc1 |w:16.17,13.14,TLB:10:11:18:14.15| Show InChI InChI=1S/C22H29N2O2S/c1-16-11-12-27-21(16)15-23(17-7-5-4-6-8-17)22(25)26-20-13-18-9-10-19(14-20)24(18,2)3/h4-8,11-12,18-20H,9-10,13-15H2,1-3H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223980 (3-(benzyl-phenyl-carbamoyloxy)-8,8-dimethyl-8-azon...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C23H29N2O2/c1-25(2)20-13-14-21(25)16-22(15-20)27-23(26)24(19-11-7-4-8-12-19)17-18-9-5-3-6-10-18/h3-12,20-22H,13-17H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223980 (3-(benzyl-phenyl-carbamoyloxy)-8,8-dimethyl-8-azon...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C23H29N2O2/c1-25(2)20-13-14-21(25)16-22(15-20)27-23(26)24(19-11-7-4-8-12-19)17-18-9-5-3-6-10-18/h3-12,20-22H,13-17H2,1-2H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223983 (3-(cyclohexylmethyl-thiophen-3-yl-carbamoyloxy)-8,...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(CC1CCCCC1)c1ccsc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H33N2O2S/c1-23(2)18-8-9-19(23)13-20(12-18)25-21(24)22(17-10-11-26-15-17)14-16-6-4-3-5-7-16/h10-11,15-16,18-20H,3-9,12-14H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50401890 (CHEMBL2206606) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1 |r,TLB:28:31:34:38.37.36,THB:32:33:36:40.31.39,32:31:34.33.38:36,39:31:34:38.37.36,39:37:34:40.32.31| Show InChI InChI=1S/C34H46N4O5/c1-22(2)43-32(41)27-7-9-28(10-8-27)36-33(42)37-30(18-23-5-11-29(39)12-6-23)31(40)35-13-14-38(3,4)34-19-24-15-25(20-34)17-26(16-24)21-34/h5-12,22,24-26,30H,13-21H2,1-4H3,(H3-,35,36,37,39,40,41,42)/p+1/t24?,25?,26?,30-,34?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223993 (8,8-dimethyl-3-[(3-methyl-thiophen-2-ylmethyl)-phe...) Show SMILES Cc1ccsc1CN(C(=O)OC1CC2CCC(C1)[N+]2(C)C)c1ccccc1 |w:16.17,13.14,TLB:10:11:18:14.15| Show InChI InChI=1S/C22H29N2O2S/c1-16-11-12-27-21(16)15-23(17-7-5-4-6-8-17)22(25)26-20-13-18-9-10-19(14-20)24(18,2)3/h4-8,11-12,18-20H,9-10,13-15H2,1-3H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223994 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl thiophen-3...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccsc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C18H22N2O2S2/c1-19-14-2-3-15(19)9-17(8-14)22-18(21)20(16-5-7-24-12-16)10-13-4-6-23-11-13/h4-7,11-12,14-15,17H,2-3,8-10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223976 (8,8-dimethyl-3-(thiophen-3-yl-thiophen-3-ylmethyl-...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccsc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C19H25N2O2S2/c1-21(2)16-3-4-17(21)10-18(9-16)23-19(22)20(15-6-8-25-13-15)11-14-5-7-24-12-14/h5-8,12-13,16-18H,3-4,9-11H2,1-2H3/q+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50401881 (CHEMBL2206587) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](C)(Cc3ccc4OCOc4c3)CC2)cc1 |r| Show InChI InChI=1S/C33H38N4O7/c1-22(2)44-32(40)25-7-9-26(10-8-25)34-33(41)35-28(18-23-4-11-27(38)12-5-23)31(39)36-14-16-37(3,17-15-36)20-24-6-13-29-30(19-24)43-21-42-29/h4-13,19,22,28H,14-18,20-21H2,1-3H3,(H2-,34,35,38,40,41)/p+1/t28-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223964 (3-(benzyl-thiophen-3-yl-carbamoyloxy)-8,8-dimethyl...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1ccsc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)18-8-9-19(23)13-20(12-18)25-21(24)22(17-10-11-26-15-17)14-16-6-4-3-5-7-16/h3-7,10-11,15,18-20H,8-9,12-14H2,1-2H3/q+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.9	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223963 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl benzyl(thi...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1ccsc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C20H24N2O2S/c1-21-16-7-8-17(21)12-19(11-16)24-20(23)22(18-9-10-25-14-18)13-15-5-3-2-4-6-15/h2-6,9-10,14,16-17,19H,7-8,11-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10.9	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223983 (3-(cyclohexylmethyl-thiophen-3-yl-carbamoyloxy)-8,...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(CC1CCCCC1)c1ccsc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H33N2O2S/c1-23(2)18-8-9-19(23)13-20(12-18)25-21(24)22(17-10-11-26-15-17)14-16-6-4-3-5-7-16/h10-11,15-16,18-20H,3-9,12-14H2,1-2H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11.3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223970 (3-(furan-3-ylmethyl-phenyl-carbamoyloxy)-8,8-dimet...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccoc1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O3/c1-23(2)18-8-9-19(23)13-20(12-18)26-21(24)22(14-16-10-11-25-15-16)17-6-4-3-5-7-17/h3-7,10-11,15,18-20H,8-9,12-14H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223990 (8,8-dimethyl-3-(phenyl-thiophen-2-ylmethyl-carbamo...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1cccs1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)17-10-11-18(23)14-19(13-17)25-21(24)22(15-20-9-6-12-26-20)16-7-4-3-5-8-16/h3-9,12,17-19H,10-11,13-15H2,1-2H3/q+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50401890 (CHEMBL2206606) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1 |r,TLB:28:31:34:38.37.36,THB:32:33:36:40.31.39,32:31:34.33.38:36,39:31:34:38.37.36,39:37:34:40.32.31| Show InChI InChI=1S/C34H46N4O5/c1-22(2)43-32(41)27-7-9-28(10-8-27)36-33(42)37-30(18-23-5-11-29(39)12-6-23)31(40)35-13-14-38(3,4)34-19-24-15-25(20-34)17-26(16-24)21-34/h5-12,22,24-26,30H,13-21H2,1-4H3,(H3-,35,36,37,39,40,41,42)/p+1/t24?,25?,26?,30-,34?/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13.1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M1 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50401890 (CHEMBL2206606) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(C)C23CC4CC(CC(C4)C2)C3)cc1 |r,TLB:28:31:34:38.37.36,THB:32:33:36:40.31.39,32:31:34.33.38:36,39:31:34:38.37.36,39:37:34:40.32.31| Show InChI InChI=1S/C34H46N4O5/c1-22(2)43-32(41)27-7-9-28(10-8-27)36-33(42)37-30(18-23-5-11-29(39)12-6-23)31(40)35-13-14-38(3,4)34-19-24-15-25(20-34)17-26(16-24)21-34/h5-12,22,24-26,30H,13-21H2,1-4H3,(H3-,35,36,37,39,40,41,42)/p+1/t24?,25?,26?,30-,34?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13.1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50401898 (CHEMBL2207177) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H](C2)[N+](C)(C)Cc2ccc(Cl)cc2)cc1 |r| Show InChI InChI=1S/C34H41ClN4O5/c1-23(2)44-33(42)26-11-15-28(16-12-26)36-34(43)37-31(20-24-9-17-30(40)18-10-24)32(41)38-19-5-6-29(21-38)39(3,4)22-25-7-13-27(35)14-8-25/h7-18,23,29,31H,5-6,19-22H2,1-4H3,(H2-,36,37,40,42,43)/p+1/t29-,31+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13.3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223994 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl thiophen-3...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccsc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C18H22N2O2S2/c1-19-14-2-3-15(19)9-17(8-14)22-18(21)20(16-5-7-24-12-16)10-13-4-6-23-11-13/h4-7,11-12,14-15,17H,2-3,8-10H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13.8	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223991 (3-(benzyl-thiophen-2-yl-carbamoyloxy)-8,8-dimethyl...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1cccs1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)17-10-11-18(23)14-19(13-17)25-21(24)22(20-9-6-12-26-20)15-16-7-4-3-5-8-16/h3-9,12,17-19H,10-11,13-15H2,1-2H3/q+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13.8	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50401891 (CHEMBL2206605) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+](C)(Cc2ccc3ccccc3c2)Cc2ccc3ccccc3c2)cc1 |r| Show InChI InChI=1S/C45H46N4O5/c1-31(2)54-44(52)37-18-20-40(21-19-37)47-45(53)48-42(28-32-14-22-41(50)23-15-32)43(51)46-24-25-49(3,29-33-12-16-35-8-4-6-10-38(35)26-33)30-34-13-17-36-9-5-7-11-39(36)27-34/h4-23,26-27,31,42H,24-25,28-30H2,1-3H3,(H3-,46,47,48,50,51,52,53)/p+1/t42-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223987 (8,8-dimethyl-3-[(3-methyl-furan-2-ylmethyl)-phenyl...) Show SMILES Cc1ccoc1CN(C(=O)OC1CC2CCC(C1)[N+]2(C)C)c1ccccc1 |w:16.17,13.14,TLB:10:11:18:14.15| Show InChI InChI=1S/C22H29N2O3/c1-16-11-12-26-21(16)15-23(17-7-5-4-6-8-17)22(25)27-20-13-18-9-10-19(14-20)24(18,2)3/h4-8,11-12,18-20H,9-10,13-15H2,1-3H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223995 (8,8-dimethyl-3-[(5-methyl-thiophen-2-ylmethyl)-phe...) Show SMILES Cc1ccc(CN(C(=O)OC2CC3CCC(C2)[N+]3(C)C)c2ccccc2)s1 |w:15.15,12.12,TLB:9:10:17:13.14| Show InChI InChI=1S/C22H29N2O2S/c1-16-9-12-21(27-16)15-23(17-7-5-4-6-8-17)22(25)26-20-13-18-10-11-19(14-20)24(18,2)3/h4-9,12,18-20H,10-11,13-15H2,1-3H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223970 (3-(furan-3-ylmethyl-phenyl-carbamoyloxy)-8,8-dimet...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccoc1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O3/c1-23(2)18-8-9-19(23)13-20(12-18)26-21(24)22(14-16-10-11-25-15-16)17-6-4-3-5-7-17/h3-7,10-11,15,18-20H,8-9,12-14H2,1-2H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223963 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl benzyl(thi...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1ccsc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C20H24N2O2S/c1-21-16-7-8-17(21)12-19(11-16)24-20(23)22(18-9-10-25-14-18)13-15-5-3-2-4-6-15/h2-6,9-10,14,16-17,19H,7-8,11-13H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19.1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223994 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl thiophen-3...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccsc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C18H22N2O2S2/c1-19-14-2-3-15(19)9-17(8-14)22-18(21)20(16-5-7-24-12-16)10-13-4-6-23-11-13/h4-7,11-12,14-15,17H,2-3,8-10H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19.6	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223992 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl phenyl(thi...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1cccs1)c1ccccc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C20H24N2O2S/c1-21-16-9-10-17(21)13-18(12-16)24-20(23)22(14-19-8-5-11-25-19)15-6-3-2-4-7-15/h2-8,11,16-18H,9-10,12-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20.3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223995 (8,8-dimethyl-3-[(5-methyl-thiophen-2-ylmethyl)-phe...) Show SMILES Cc1ccc(CN(C(=O)OC2CC3CCC(C2)[N+]3(C)C)c2ccccc2)s1 |w:15.15,12.12,TLB:9:10:17:13.14| Show InChI InChI=1S/C22H29N2O2S/c1-16-9-12-21(27-16)15-23(17-7-5-4-6-8-17)22(25)26-20-13-18-10-11-19(14-20)24(18,2)3/h4-9,12,18-20H,10-11,13-15H2,1-3H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223984 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl benzyl(thi...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1cccs1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C20H24N2O2S/c1-21-16-9-10-17(21)13-18(12-16)24-20(23)22(19-8-5-11-25-19)14-15-6-3-2-4-7-15/h2-8,11,16-18H,9-10,12-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22.9	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223984 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl benzyl(thi...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1cccs1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C20H24N2O2S/c1-21-16-9-10-17(21)13-18(12-16)24-20(23)22(19-8-5-11-25-19)14-15-6-3-2-4-7-15/h2-8,11,16-18H,9-10,12-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26.5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50401879 (CHEMBL2206589) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](Cc3ccc(Cl)cc3)(CC2)C(C)C)cc1 |r| Show InChI InChI=1S/C34H41ClN4O5/c1-23(2)39(22-26-5-11-28(35)12-6-26)19-17-38(18-20-39)32(41)31(21-25-7-15-30(40)16-8-25)37-34(43)36-29-13-9-27(10-14-29)33(42)44-24(3)4/h5-16,23-24,31H,17-22H2,1-4H3,(H2-,36,37,40,42,43)/p+1/t31-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27.5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223960 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl phenyl(thi...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccccc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C20H24N2O2S/c1-21-17-7-8-18(21)12-19(11-17)24-20(23)22(13-15-9-10-25-14-15)16-5-3-2-4-6-16/h2-6,9-10,14,17-19H,7-8,11-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27.5	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223981 (8,8-dimethyl-3-(phenyl-thiophen-3-ylmethyl-carbamo...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccsc1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C21H27N2O2S/c1-23(2)18-8-9-19(23)13-20(12-18)25-21(24)22(14-16-10-11-26-15-16)17-6-4-3-5-7-17/h3-7,10-11,15,18-20H,8-9,12-14H2,1-2H3/q+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50401888 (CHEMBL2206608) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCCC2)cc1 |r| Show InChI InChI=1S/C34H41ClN4O5/c1-24(2)44-33(42)27-10-14-29(15-11-27)37-34(43)38-31(22-25-8-16-30(40)17-9-25)32(41)36-18-21-39(19-4-3-5-20-39)23-26-6-12-28(35)13-7-26/h6-17,24,31H,3-5,18-23H2,1-2H3,(H3-,36,37,38,40,41,42,43)/p+1/t31-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33.4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50223961 (3-[(4-bromo-benzyl)-phenyl-carbamoyloxy]-8,8-dimet...) Show SMILES C[N+]1(C)C2CCC1CC(C2)OC(=O)N(Cc1ccc(Br)cc1)c1ccccc1 |w:6.7,3.3,THB:10:8:1:4.5| Show InChI InChI=1S/C23H28BrN2O2/c1-26(2)20-12-13-21(26)15-22(14-20)28-23(27)25(19-6-4-3-5-7-19)16-17-8-10-18(24)11-9-17/h3-11,20-22H,12-16H2,1-2H3/q+1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33.4	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223993 (8,8-dimethyl-3-[(3-methyl-thiophen-2-ylmethyl)-phe...) Show SMILES Cc1ccsc1CN(C(=O)OC1CC2CCC(C1)[N+]2(C)C)c1ccccc1 |w:16.17,13.14,TLB:10:11:18:14.15| Show InChI InChI=1S/C22H29N2O2S/c1-16-11-12-27-21(16)15-23(17-7-5-4-6-8-17)22(25)26-20-13-18-9-10-19(14-20)24(18,2)3/h4-8,11-12,18-20H,9-10,13-15H2,1-3H3/q+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34.7	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223992 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl phenyl(thi...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1cccs1)c1ccccc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C20H24N2O2S/c1-21-16-9-10-17(21)13-18(12-16)24-20(23)22(14-19-8-5-11-25-19)15-6-3-2-4-7-15/h2-8,11,16-18H,9-10,12-14H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50223963 (8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl benzyl(thi...) Show SMILES CN1C2CCC1CC(C2)OC(=O)N(Cc1ccccc1)c1ccsc1 |w:5.6,2.2,THB:9:7:1:3.4| Show InChI InChI=1S/C20H24N2O2S/c1-21-16-7-8-17(21)12-19(11-16)24-20(23)22(18-9-10-25-14-18)13-15-5-3-2-4-6-15/h2-6,9-10,14,16-17,19H,7-8,11-13H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39.1	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50401877 (CHEMBL2206591) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CC[N+](CC3CCc4ccccc4C3)(Cc3ccc(Cl)cc3)CC2)cc1 |r| Show InChI InChI=1S/C42H47ClN4O5/c1-29(2)52-41(50)34-13-17-37(18-14-34)44-42(51)45-39(26-30-10-19-38(48)20-11-30)40(49)46-21-23-47(24-22-46,27-31-8-15-36(43)16-9-31)28-32-7-12-33-5-3-4-6-35(33)25-32/h3-6,8-11,13-20,29,32,39H,7,12,21-28H2,1-2H3,(H2-,44,45,48,50,51)/p+1/t32?,39-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41.2	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M2 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50223987 (8,8-dimethyl-3-[(3-methyl-furan-2-ylmethyl)-phenyl...) Show SMILES Cc1ccoc1CN(C(=O)OC1CC2CCC(C1)[N+]2(C)C)c1ccccc1 |w:16.17,13.14,TLB:10:11:18:14.15| Show InChI InChI=1S/C22H29N2O3/c1-16-11-12-26-21(16)15-23(17-7-5-4-6-8-17)22(25)27-20-13-18-9-10-19(14-20)24(18,2)3/h4-8,11-12,18-20H,9-10,13-15H2,1-3H3/q+1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42.3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithkline Curated by ChEMBL					Assay Description Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization				Bioorg Med Chem Lett 17: 6066-9 (2007) Article DOI: 10.1016/j.bmcl.2007.09.071 BindingDB Entry DOI: 10.7270/Q2BC3Z8T
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50401889 (CHEMBL2206607) Show SMILES CC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC[N+]2(Cc3ccc(Cl)cc3)CCCC2)cc1 |r| Show InChI InChI=1S/C33H39ClN4O5/c1-23(2)43-32(41)26-9-13-28(14-10-26)36-33(42)37-30(21-24-7-15-29(39)16-8-24)31(40)35-17-20-38(18-3-4-19-38)22-25-5-11-27(34)12-6-25/h5-16,23,30H,3-4,17-22H2,1-2H3,(H3-,35,36,37,39,40,41,42)/p+1/t30-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	44.9	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Antagonist activity at human muscarinic M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization by FL...				Bioorg Med Chem Lett 22: 7087-91 (2012) Article DOI: 10.1016/j.bmcl.2012.09.085 BindingDB Entry DOI: 10.7270/Q2ZK5HT1
					More data for this Ligand-Target Pair

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