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TargetMuscarinic acetylcholine receptor M3
LigandBDBM50401898
Substrate/Competitorn/a
Meas. Tech.ChEMBL_886299 (CHEMBL2212342)
IC50 13.3±n/a nM
Citation Jin, Q; Davis, RS; Bullion, AM; Jin, J; Wang, Y; Widdowson, KL; Palovich, MR; Foley, JJ; Schmidt, DB; Buckley, PT; Webb, EF; Salmon, M; Belmonte, KE; Sarau, HM; Busch-Petersen, J Tyrosine urea muscarinic acetylcholine receptor antagonists: achiral quaternary ammonium groups. Bioorg Med Chem Lett22:7087-91 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M3
Name:Muscarinic acetylcholine receptor M3
Synonyms:ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3
Type:Enzyme
Mol. Mass.:66151.03
Organism:Homo sapiens (Human)
Description:P20309
Residue:590
Sequence:
MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50401898
n/a
NameBDBM50401898
Synonyms:CHEMBL2207177
TypeSmall organic molecule
Emp. Form.C34H42ClN4O5
Mol. Mass.622.174
SMILESCC(C)OC(=O)c1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N2CCC[C@H](C2)[N+](C)(C)Cc2ccc(Cl)cc2)cc1 |r|
Structure
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