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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase Chk2 | ||
| Ligand | BDBM50224992 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_458529 (CHEMBL942788) | ||
| IC50 | 80±n/a nM | ||
| Citation |  Neff, DK; Lee-Dutra, A; Blevitt, JM; Axe, FU; Hack, MD; Buma, JC; Rynberg, R; Brunmark, A; Karlsson, L; Breitenbucher, JG 2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2. Bioorg Med Chem Lett17:6467-71 (2007) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase Chk2 | |||
| Name: | Serine/threonine-protein kinase Chk2 | ||
| Synonyms: | CDS1 | CHEK2 | CHK2 | CHK2_HUMAN | Checkpoint Kinase (Chk2) | RAD53 | Serine/threonine-protein kinase Chek2 | Serine/threonine-protein kinase Chk1/2 | ||
| Type: | Protein | ||
| Mol. Mass.: | 60908.59 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O96017 | ||
| Residue: | 543 | ||
| Sequence: |
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| BDBM50224992 | |||
| n/a | |||
| Name | BDBM50224992 | ||
| Synonyms: | 2-(4-(4-hydroxycyclohexyloxy)phenyl)-1H-benzo[d]imidazole-5-carboxamide | CHEMBL249569 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H21N3O3 | ||
| Mol. Mass. | 351.399 | ||
| SMILES | NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(OC2CCC(O)CC2)cc1 |(11.67,-7.06,;13.01,-6.28,;13.01,-4.74,;14.34,-7.05,;14.34,-8.6,;15.67,-9.37,;17.01,-8.59,;18.48,-9.06,;19.38,-7.81,;18.47,-6.56,;17,-7.05,;15.67,-6.28,;20.92,-7.8,;21.7,-9.13,;23.23,-9.12,;24,-7.78,;25.54,-7.77,;26.3,-6.43,;27.83,-6.42,;28.59,-5.09,;27.82,-3.76,;28.59,-2.42,;26.28,-3.77,;25.51,-5.11,;23.21,-6.45,;21.68,-6.46,)| | ||
| Structure | 
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