Reaction Details |
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Target | Gonadotropin-releasing hormone receptor |
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Ligand | BDBM50225083 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_458544 (CHEMBL942802) |
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IC50 | 345±n/a nM |
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Citation | Arnould, JC; Delouvrié, B; Boutron, P; Dossetter, AG; Foote, KM; Hamon, A; Hancox, U; Harris, CS; Hutton, M; Lamorlette, M; Matusiak, Z Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor. Bioorg Med Chem Lett17:6448-54 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Gonadotropin-releasing hormone receptor |
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Name: | Gonadotropin-releasing hormone receptor |
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) |
Type: | Enzyme |
Mol. Mass.: | 37749.45 |
Organism: | Homo sapiens (Human) |
Description: | P30968 |
Residue: | 328 |
Sequence: | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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BDBM50225083 |
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n/a |
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Name | BDBM50225083 |
Synonyms: | CHEMBL401351 | N-(1-(2-(4-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl)ethyl)piperazin-1-yl)acetyl)pyrrolidin-3-yl)acetamide |
Type | Small organic molecule |
Emp. Form. | C38H52N6O3S |
Mol. Mass. | 672.923 |
SMILES | CC(=O)NC1CCN(C1)C(=O)CN1CCN(CCc2c([nH]c3sc(cc23)C(C)(C)C(=O)N2C3CCC2CC3)-c2cc(C)cc(C)c2)CC1 |w:4.3,THB:29:31:33.34:36.37| |
Structure |
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