| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50225083 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_458545 (CHEMBL942803) |
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| IC50 | 104±n/a nM |
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| Citation |  Arnould, JC; Delouvrié, B; Boutron, P; Dossetter, AG; Foote, KM; Hamon, A; Hancox, U; Harris, CS; Hutton, M; Lamorlette, M; Matusiak, Z Synthesis and structure-activity relationships of thieno[2,3-b]pyrroles as antagonists of the GnRH receptor. Bioorg Med Chem Lett17:6448-54 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37767.60 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1335047 |
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| Residue: | 327 |
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| Sequence: | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKL
QRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRM
IYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50225083 |
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| n/a |
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| Name | BDBM50225083 |
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| Synonyms: | CHEMBL401351 | N-(1-(2-(4-(2-(2-(1-(7-aza-bicyclo[2.2.1]heptan-7-yl)-2-methyl-1-oxopropan-2-yl)-5-(3,5-dimethylphenyl)-6H-thieno[2,3-b]pyrrol-4-yl)ethyl)piperazin-1-yl)acetyl)pyrrolidin-3-yl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C38H52N6O3S |
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| Mol. Mass. | 672.923 |
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| SMILES | CC(=O)NC1CCN(C1)C(=O)CN1CCN(CCc2c([nH]c3sc(cc23)C(C)(C)C(=O)N2C3CCC2CC3)-c2cc(C)cc(C)c2)CC1 |w:4.3,THB:29:31:33.34:36.37| |
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| Structure | 
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