| Reaction Details |
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 | Report a problem with these data |
| Target | Transthyretin |
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| Ligand | BDBM50225217 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_451108 (CHEMBL900187) |
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| pH | 4.4±n/a |
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| IC50 | 850±n/a nM |
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| Comments | extracted |
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| Citation |  Gupta, S; Chhibber, M; Sinha, S; Surolia, A Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. J Med Chem50:5589-99 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Transthyretin |
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| Name: | Transthyretin |
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| Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 15884.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P02766 |
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| Residue: | 147 |
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| Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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| BDBM50225217 |
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| n/a |
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| Name | BDBM50225217 |
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| Synonyms: | 5-(chloromethyl)-2-(2,4-dichlorophenoxy)phenol | CHEMBL240805 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9Cl3O2 |
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| Mol. Mass. | 303.568 |
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| SMILES | Oc1cc(CCl)ccc1Oc1ccc(Cl)cc1Cl |
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| Structure | 
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