| Reaction Details |
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 | Report a problem with these data |
| Target | Stromelysin-1 |
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| Ligand | BDBM50227730 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_459991 (CHEMBL944034) |
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| IC50 | 51±n/a nM |
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| Citation |  Whitlock, GA; Dack, KN; Dickinson, RP; Lewis, ML A novel series of highly selective inhibitors of MMP-3. Bioorg Med Chem Lett17:6750-3 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stromelysin-1 |
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| Name: | Stromelysin-1 |
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| Synonyms: | MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 53973.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08254 |
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| Residue: | 477 |
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| Sequence: | MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
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| BDBM50227730 |
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| n/a |
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| Name | BDBM50227730 |
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| Synonyms: | CHEMBL398640 | N-hydroxy-2-[4-(2-methyl-3'-trifluoromethoxy-biphenyl-4-yl)-3,6-dihydro-2H-pyridine-1-sulfonyl]-acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F3N2O5S |
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| Mol. Mass. | 470.462 |
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| SMILES | Cc1cc(ccc1-c1cccc(OC(F)(F)F)c1)C1=CCN(CC1)S(=O)(=O)CC(=O)NO |t:20| |
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| Structure | 
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