| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor delta |
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| Ligand | BDBM50227758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_452362 (CHEMBL902601) |
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| EC50 | 87±n/a nM |
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| Citation |  Shi, Q; Canada, EJ; Xu, Y; Warshawsky, AM; Etgen, GJ; Broderick, CL; Clutinger, CK; Irwin, LA; Laurila, ME; Montrose-Rafizadeh, C; Oldham, BA; Wang, M; Winneroski, LL; Xie, C; York, JS; Yumibe, NP; Zink, RW; Mantlo, N Design and synthesis of novel and potent amide linked PPARgamma/delta dual agonists. Bioorg Med Chem Lett17:6744-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor delta |
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| Name: | Peroxisome proliferator-activated receptor delta |
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| Synonyms: | NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 49910.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q03181 |
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| Residue: | 441 |
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| Sequence: | MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
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| BDBM50227758 |
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| n/a |
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| Name | BDBM50227758 |
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| Synonyms: | 3-(4-(3-((5-chloro-1-methyl-1H-indole-2-carboxamido)methyl)phenoxy)-2-methylphenyl)propanoic acid | CHEMBL399417 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25ClN2O4 |
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| Mol. Mass. | 476.951 |
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| SMILES | Cc1cc(Oc2cccc(CNC(=O)c3cc4cc(Cl)ccc4n3C)c2)ccc1CCC(O)=O |
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| Structure | 
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