Reaction Details |
| Report a problem with these data |
Target | High affinity nerve growth factor receptor |
---|
Ligand | BDBM50229096 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_461738 (CHEMBL928869) |
---|
IC50 | 520±n/a nM |
---|
Citation | Kim, SH; Tokarski, JS; Leavitt, KJ; Fink, BE; Salvati, ME; Moquin, R; Obermeier, MT; Trainor, GL; Vite, GG; Stadnick, LK; Lippy, JS; You, D; Lorenzi, MV; Chen, P Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA. Bioorg Med Chem Lett18:634-9 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
High affinity nerve growth factor receptor |
---|
Name: | High affinity nerve growth factor receptor |
Synonyms: | 2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA |
Type: | n/a |
Mol. Mass.: | 87498.18 |
Organism: | Homo sapiens (Human) |
Description: | P04629 |
Residue: | 796 |
Sequence: | MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLH
HLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRL
NLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQ
GPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMK
SGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWC
IPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYT
LLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSV
AVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTE
GKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKML
VAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRF
LRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ
GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEI
FTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHAR
LQALAQAPPVYLDVLG
|
|
|
BDBM50229096 |
---|
n/a |
---|
Name | BDBM50229096 |
Synonyms: | 1-(4-(3-(2-(5-bromopyridin-2-ylamino)thiazol-5-ylthio)benzoyl)piperazin-1-yl)ethanone | CHEMBL251789 |
Type | Small organic molecule |
Emp. Form. | C21H20BrN5O2S2 |
Mol. Mass. | 518.45 |
SMILES | CC(=O)N1CCN(CC1)C(=O)c1cccc(Sc2cnc(Nc3ccc(Br)cn3)s2)c1 |
Structure |
|