Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50229596 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_460136 (CHEMBL924983) |
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Ki | 4.5±n/a nM |
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Citation | Briard, E; Zoghbi, SS; Imaizumi, M; Gourley, JP; Shetty, HU; Hong, J; Cropley, V; Fujita, M; Innis, RB; Pike, VW Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo. J Med Chem51:17-30 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor-related protein | Peripheral-type benzodiazepine receptor | TSPO | TSPO_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 18834.74 |
Organism: | Homo sapiens (Human) |
Description: | P30536 |
Residue: | 169 |
Sequence: | MAPPWVPAMGFTLAPSLGCFVGSRFVHGEGLRWYAGLQKPSWHPPHWVLGPVWGTLYSAM
GYGSYLVWKELGGFTEKAVVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLLLVSGAAA
ATTVAWYQVSPLAARLLYPYLAWLAFTTTLNYCVWRDNHGWRGGRRLPE
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BDBM50229596 |
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n/a |
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Name | BDBM50229596 |
Synonyms: | 1-(2-chlorophenyl)-N-methyl-N-[(1S)-1-methylpropyl]isoquinoline-3-carboxamide | CHEMBL251953 | PK-11195 |
Type | Small organic molecule |
Emp. Form. | C21H21ClN2O |
Mol. Mass. | 352.857 |
SMILES | CC[C@H](C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl |
Structure |
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