| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C epsilon type |
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| Ligand | BDBM50185931 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_460214 (CHEMBL927264) |
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| Ki | 510±n/a nM |
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| Citation |  Yanagita, RC; Nakagawa, Y; Yamanaka, N; Kashiwagi, K; Saito, N; Irie, K Synthesis, conformational analysis, and biological evaluation of 1-hexylindolactam-V10 as a selective activator for novel protein kinase C isozymes. J Med Chem51:46-56 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C epsilon type |
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| Name: | Protein kinase C epsilon type |
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| Synonyms: | KPCE_HUMAN | PKC epsilon | PKCE | PRKCE | Protein kinase C epsilon | Protein kinase C epsilon type | Protein kinase C, PKC; classical/novel | Protein kinase C, epsilon | nPKC-epsilon |
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| Type: | Enzyme |
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| Mol. Mass.: | 83680.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 737 |
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| Sequence: | MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT
NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE
PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP
TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN
MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA
KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE
NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG
KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD
RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL
DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED
AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI
NQEEFKGFSYFGEDLMP
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| BDBM50185931 |
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| n/a |
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| Name | BDBM50185931 |
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| Synonyms: | 8-Octyl-benzolactam-V9 | CHEMBL206866 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H40N2O2 |
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| Mol. Mass. | 388.5866 |
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| SMILES | CCCCCCCCc1cccc2N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)CCc12 |
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| Structure | 
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