| Reaction Details |
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 | Report a problem with these data |
| Target | Alpha-amylase |
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| Ligand | BDBM18351 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_462051 (CHEMBL945826) |
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| IC50 | 1670±n/a nM |
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| Citation |  Zhou, Y; Zhao, Y; O' Boyle, KM; Murphy, PV Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. Bioorg Med Chem Lett18:954-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alpha-amylase |
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| Name: | Alpha-amylase |
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| Synonyms: | Alpha-glucosidase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65231.69 |
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| Organism: | Bacillus stearothermophilus |
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| Description: | ChEMBL_740884 |
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| Residue: | 555 |
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| Sequence: | MKKTWWKEGVAYQIYPRSFMDANGDGIGDLRGIIEKLDYLVELGVDIVWICPIYRSPNAD
NGYDISDYYAIMDEFGTMDDFDELLAQAHRRGLKIILDLVINHTSDEHPWFIESRSSRDN
PKRDWYIWRDGKDGREPNNWESIFGGSAWQYDERTGQYYLHLFDVKQPDLNWENSEVRQA
LYDMINWWLDKGIDGFRIDAISHIKKKPGLPDLPNPKGLKYVPSFAAHMNQPGIMEYLRE
LKEQTFARYDIMTVGEANGVTVDEAEQWVGEENGVFHMIFQFEHLGLWKRKADGSIDVRR
LKRTLTKWQKGLENRGWNALFLENHDLPRSVSTWGNDREYWAESAKALGALYFFMQGTPF
IYQGQEIGMTNVQFSDIRDYRDVAALRLYELERANGRTHEEVMKIIWKTGRDNSRTPMQW
SDAPNAGFTTGTPWIKVNENYRTINVEAERRDPNSVWSFYRQMIQLRKANELFVYGAYDL
LLENHPSIYAYTRTLGRDRALIIVNVSDRPSLYRYDGFRLQSSDLALSNYPVRPHKNATR
FKLKPYEARVYIWKE
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| BDBM18351 |
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| n/a |
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| Name | BDBM18351 |
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| Synonyms: | (2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 10 | (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol | 1-Deoxynojirimycin | 1-deoxynojirimycin (DNJ) | CHEMBL307429 | US20230339856, Compound DNJ | US9181184, 1 | dNM |
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| Type | natural product |
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| Emp. Form. | C6H13NO4 |
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| Mol. Mass. | 163.1717 |
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| SMILES | OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O |
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| Structure | 
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