Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50231911 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_462097 (CHEMBL944929) | ||
| Ki | 1063±n/a nM | ||
| Citation |  Yoon, T; De Lombaert, S; Brodbeck, R; Gulianello, M; Chandrasekhar, J; Horvath, RF; Ge, P; Kershaw, MT; Krause, JE; Kehne, J; Hoffman, D; Doller, D; Hodgetts, KJ The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists. Bioorg Med Chem Lett18:891-6 (2008) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50231911 | |||
| n/a | |||
| Name | BDBM50231911 | ||
| Synonyms: | CHEMBL252301 | N-(2-(1H-imidazol-1-yl)ethyl)-1-(2-methoxy-4,6-dimethylphenyl)-3-methyl-N-propylisoquinolin-4-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H32N4O | ||
| Mol. Mass. | 428.5692 | ||
| SMILES | CCCN(CCn1ccnc1)c1c(C)nc(-c2c(C)cc(C)cc2OC)c2ccccc12 |(25.87,-11.85,;27.21,-12.62,;27.22,-14.16,;28.56,-14.92,;29.89,-14.14,;29.88,-12.6,;31.21,-11.83,;31.36,-10.29,;32.86,-9.96,;33.64,-11.29,;32.61,-12.44,;28.56,-16.46,;27.24,-17.23,;25.9,-16.46,;27.24,-18.78,;28.57,-19.55,;28.57,-21.08,;27.24,-21.85,;25.9,-21.08,;27.24,-23.39,;28.57,-24.16,;28.57,-25.7,;29.91,-23.38,;29.9,-21.84,;31.23,-21.07,;32.57,-21.84,;29.91,-18.77,;31.23,-19.53,;32.58,-18.76,;32.57,-17.21,;31.23,-16.45,;29.9,-17.22,)| | ||
| Structure | 
| ||