| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50091468 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_462279 (CHEMBL946042) |
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| Ki | 1200±n/a nM |
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| Citation |  Srikanth, K; Nair, PC; Sobhia, ME Probing the structural and topological requirements for CCR2 antagonism: holographic QSAR for indolopiperidine derivatives. Bioorg Med Chem Lett18:1450-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50091468 |
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| n/a |
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| Name | BDBM50091468 |
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| Synonyms: | (E)-3-(4-Dimethylamino-phenyl)-N-{5-[4-(1H-indol-3-yl)-piperidin-1-yl]-pentyl}-acrylamide | (E)-N-(5-(4-(1H-indol-3-yl)piperidin-1-yl)pentyl)-3-(4-(dimethylamino)phenyl)acrylamide | CHEMBL49994 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H38N4O |
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| Mol. Mass. | 458.6382 |
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| SMILES | CN(C)c1ccc(\C=C\C(=O)NCCCCCN2CCC(CC2)c2c[nH]c3ccccc23)cc1 |
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| Structure | 
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