Ki Summary

Reaction Details

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Target

Casein kinase I isoform alpha

Ligand

BDBM50260229

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_508723 (CHEMBL1004017)

IC50

1300±n/a nM

Citation

Quintavalle, M; Sambucini, S; Summa, V; Orsatti, L; Talamo, F; De Francesco, R; Neddermann, P Hepatitis C virus NS5A is a direct substrate of casein kinase I-alpha, a cellular kinase identified by inhibitor affinity chromatography using specific NS5A hyperphosphorylation inhibitors. J Biol Chem282:5536-44 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Casein kinase I isoform alpha

Name:

Casein kinase I isoform alpha

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

38936.59

Organism:

Homo sapiens (Human)

Description:

P48729

Residue:

337

Sequence:

MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYE
SKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQM
ISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKN
LTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKK
MSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTM
LKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF

BDBM50260229

n/a

Name

BDBM50260229

Synonyms:

4-(4-(4-fluorophenyl)-2-(4-methylcyclohexyl)-1H-imidazol-5-yl)pyridine | CHEMBL523938

Type

Small organic molecule

Emp. Form.

C21H22FN3

Mol. Mass.

335.4179

SMILES

CC1CCC(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 |(4.64,-12.94,;3.3,-13.69,;3.28,-15.23,;1.93,-15.98,;.61,-15.19,;.63,-13.66,;1.97,-12.9,;-.73,-15.94,;-1.76,-14.8,;-3.17,-15.43,;-3.01,-16.96,;-1.5,-17.28,;-4.31,-17.78,;-5.67,-17.05,;-6.98,-17.86,;-6.92,-19.4,;-8.23,-20.22,;-5.55,-20.13,;-4.25,-19.31,;-4.5,-14.66,;-5.84,-15.44,;-7.18,-14.67,;-7.17,-13.12,;-5.84,-12.35,;-4.51,-13.11,)|

Structure