| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Parathyroid hormone/parathyroid hormone-related peptide receptor |
|---|
| Ligand | BDBM50269979 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_505703 (CHEMBL944465) |
|---|
| IC50 | 990±n/a nM |
|---|
| Citation |  Carter, PH; Liu, RQ; Foster, WR; Tamasi, JA; Tebben, AJ; Favata, M; Staal, A; Cvijic, ME; French, MH; Dell, V; Apanovitch, D; Lei, M; Zhao, Q; Cunningham, M; Decicco, CP; Trzaskos, JM; Feyen, JH Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe. Proc Natl Acad Sci U S A104:6846-51 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Parathyroid hormone/parathyroid hormone-related peptide receptor |
|---|
| Name: | Parathyroid hormone/parathyroid hormone-related peptide receptor |
|---|
| Synonyms: | PTH/PTHr receptor | PTH/PTHrP type I receptor | PTH1 receptor | PTH1R | PTH1R_HUMAN | PTHR | PTHR1 | Parathyroid hormone 1 receptor | Parathyroid hormone receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 66370.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | PARATHYROID HT1 0 HUMAN::Q03431 |
|---|
| Residue: | 593 |
|---|
| Sequence: | MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPA
SIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPL
GAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETRE
REVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVK
DAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWIL
VEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKK
WIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVH
YIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLA
LDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKP
GTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
|
|
|
|---|
| BDBM50269979 |
|---|
| n/a |
|---|
| Name | BDBM50269979 |
|---|
| Synonyms: | CHEMBL515170 | r-5-(2-E-cyclopropylvinyl)-t-3-ethyl-6,7-difluoro-5-(trifluoromethyl)benzo[e][1,4]-oxazepin-2(1H,3H,5H)-one |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H16F5NO2 |
|---|
| Mol. Mass. | 361.3065 |
|---|
| SMILES | CC[C@@H]1O[C@@](\C=C\C2CC2)(c2c(F)c(F)ccc2NC1=O)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
