| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50251164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_530825 (CHEMBL969380) |
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| Ki | 70000±n/a nM |
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| Citation |  Corona, P; Loriga, M; Costi, MP; Ferrari, S; Paglietti, G Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities. Eur J Med Chem43:189-203 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | Thymidylate Synthase (TS) | Thymidylate synthase | thyA |
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| Type: | n/a |
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| Mol. Mass.: | 30487.86 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 264 |
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| Sequence: | MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL
WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK
NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS
YALLVHMMAQQCDLEVGDFVWIGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF
DYRFEDFEIEGYDPHPGIKAPVAI
|
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|
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| BDBM50251164 |
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| n/a |
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| Name | BDBM50251164 |
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| Synonyms: | 2-[(4-Fluoro-phenyl)amino]-3-phenyl-5,7-diamino-quinoxaline | CHEMBL465891 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16FN5 |
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| Mol. Mass. | 345.3729 |
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| SMILES | Nc1cc(N)c2nc(c(Nc3ccc(F)cc3)nc2c1)-c1ccccc1 |
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| Structure | 
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