Reaction Details | |||
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Target | Apoptosis regulator Bcl-2 | ||
Ligand | BDBM50265723 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_492505 (CHEMBL951368) | ||
EC50 | 8018±n/a nM | ||
Citation | Frey, V; Viaud, J; Subra, G; Cauquil, N; Guichou, JF; Casara, P; Grassy, G; Chavanieu, A Structure-activity relationships of Bak derived peptides: affinity and specificity modulations by amino acid replacement. Eur J Med Chem43:966-72 (2008) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Apoptosis regulator Bcl-2 | |||
Name: | Apoptosis regulator Bcl-2 | ||
Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein | ||
Type: | Homodimer or heterodimer | ||
Mol. Mass.: | 26269.11 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P10415 | ||
Residue: | 239 | ||
Sequence: |
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BDBM50265723 | |||
n/a | |||
Name | BDBM50265723 | ||
Synonyms: | (2S,5S,8S,11S,14S)-14-((5S,8S,11S,14S,17S,20S,26S,29S)-32-amino-17,29-bis(3-amino-3-oxopropyl)-5,8-di-sec-butyl-20-(3-guanidinopropyl)-14-isobutyl-26-isopropyl-11-methyl-4,7,10,13,16,19,22,25,28,31-decaoxo-3,6,9,12,15,18,21,24,27,30-decaazadotriacontanamido)-5-(2-amino-2-oxoethyl)-11-(carboxymethyl)-2-(3-guanidinopropyl)-8-(4-nitrobenzyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazahexadecane-1,16-dioic acid | CHEMBL510860 | ||
Type | Small organic molecule | ||
Emp. Form. | C75H122N26O26 | ||
Mol. Mass. | 1803.9298 | ||
SMILES | [#6]-[#6]-[#6@H](-[#6])-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#7])-[#6](-[#6])-[#6])-[#6@@H](-[#6])-[#6]-[#6])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#8])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(cc1)-[#7+](-[#8-])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](-[#8])=O |r| | ||
Structure |