Ki Summary

Reaction Details

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Target

Squalene synthase

Ligand

BDBM50052351

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_520602 (CHEMBL959524)

62±n/a nM

Citation

Cammerer, SB; Jimenez, C; Jones, S; Gros, L; Lorente, SO; Rodrigues, C; Rodrigues, JC; Caldera, A; Ruiz Perez, LM; da Souza, W; Kaiser, M; Brun, R; Urbina, JA; Gonzalez Pacanowska, D; Gilbert, IH Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother51:4049-61 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Squalene synthase

Name:

Squalene synthase

Synonyms:

Farnesyltransferase, putative

Type:

PROTEIN

Mol. Mass.:

46591.20

Organism:

Trypanosoma cruzi

Description:

ChEMBL_520602

Residue:

404

Sequence:

MEYMEELYAMVRMKWRLRRIEKGIACNDEDLRFCYDILQAVSRSFAVVIMELDEEMRDAV
CIFYLVLRALDTVEDDMSIPVDFKLRELPKFHEHLHDTTWCMSGVGVGRERELLERYTHV
TRAYSRLGKAYQDVISGICERMANGMCDFLTRKVETKADYDLYCHYVAGLVGHGLTLLYV
SSGLEDVRLADDLTNANHMGLFLQKTNIIRDFYEDIREVPPRVFWPREIWEKYTDDLHAF
KDELHEAKAVECLNAMVADALVHVPHVVEYLASLRDPSVFTFSAIPQVMAMATLSLVFNN
KDVFHTKVKTTRGATARIFHYSTELQATLQMLKTYTLRLAARMNAQDACYDRIEHLVNDA
IRAMESHQKPNGESVARSMLMRYPALGGHLLYTLVDNVVGYLGK

BDBM50052351

n/a

Name

BDBM50052351

Synonyms:

3-Biphenyl-4-yl-1-aza-bicyclo[2.2.2]octan-3-ol | 3-biphenyl-4-yl-3-hydroxyquinuclidine | CHEMBL279261

Type

Small organic molecule

Emp. Form.

C19H21NO

Mol. Mass.

279.3761

SMILES

OC1(CN2CCC1CC2)c1ccc(cc1)-c1ccccc1 |(10.58,-8.89,;10.59,-10.42,;10.59,-11.97,;9.25,-12.74,;7.92,-11.97,;7.92,-10.42,;9.25,-9.65,;8.51,-11,;10,-11.41,;11.92,-9.66,;13.25,-10.43,;14.59,-9.66,;14.59,-8.12,;13.25,-7.35,;11.92,-8.12,;15.92,-7.35,;17.25,-8.12,;18.58,-7.36,;18.58,-5.81,;17.24,-5.04,;15.91,-5.82,)|

Structure