Ki Summary

Reaction Details

Report a problem with these data

Target

Squalene synthase

Ligand

BDBM50270302

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_520603 (CHEMBL959525)

IC50

490±n/a nM

Citation

Cammerer, SB; Jimenez, C; Jones, S; Gros, L; Lorente, SO; Rodrigues, C; Rodrigues, JC; Caldera, A; Ruiz Perez, LM; da Souza, W; Kaiser, M; Brun, R; Urbina, JA; Gonzalez Pacanowska, D; Gilbert, IH Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother51:4049-61 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Squalene synthase

Name:

Squalene synthase

Synonyms:

Farnesyltransferase, putative

Type:

PROTEIN

Mol. Mass.:

47117.40

Organism:

Leishmania major

Description:

ChEMBL_520603

Residue:

414

Sequence:

MGFFSDSVAMMRVKWQMRSVKIQVPPEETDLRFCYDIMNDVSRSFAVVVAQLADQQLRDA
ICIFYLVLRALDTLEDDMSVPVDVKLKELPKFHTHTSDMSWCMSGVGEGRERELLAKYPC
VSREFKKLKKEYQDVIANICERMANGMCEFLKRPVVTKDDYNQYCHYVAGLVGHGLTQLF
ARCGFEDPSLDDDLTSSNHMGLFLQKTNIIRDYYEDIREEPPRMFWPKEIWGTYVTELKE
LKSESNNAAAVQCLNAMVADALVHVPYIVDYLSALRDPSVFRFCAIPQVMAIATLKEVYN
NPDTFQVKVKVSRPESCRIMLKATTLYSSLSMFRDYCVELQEKLDMQDASSVSIANSLAA
AIERIDLQLKKCQDVSYTRSLLARYPGLGGQFLLTVMDTVAGFFGGRKEIAGHA

BDBM50270302

n/a

Name

BDBM50270302

Synonyms:

3-[7'-(Methoxy)-napht-2'-yl]-quinuclidine-2-ene | CHEMBL478981

Type

Small organic molecule

Emp. Form.

C18H19NO

Mol. Mass.

265.3496

SMILES

COc1ccc2cc(ccc2c1)C1=CN2CCC1CC2 |t:14,(.63,-19.82,;-.71,-19.06,;-2.03,-19.84,;-3.38,-19.07,;-4.71,-19.85,;-4.7,-21.38,;-6.03,-22.15,;-6.03,-23.68,;-4.7,-24.46,;-3.36,-23.69,;-3.36,-22.15,;-2.03,-21.38,;-7.36,-24.45,;-7.36,-26,;-8.7,-26.77,;-10.03,-26,;-10.03,-24.45,;-8.7,-23.67,;-9.43,-25.03,;-7.95,-25.43,)|

Structure