Ki Summary

Reaction Details

Report a problem with these data

Target

Squalene synthase

Ligand

BDBM50270322

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_520603 (CHEMBL959525)

IC50

>1000±n/a nM

Citation

Cammerer, SB; Jimenez, C; Jones, S; Gros, L; Lorente, SO; Rodrigues, C; Rodrigues, JC; Caldera, A; Ruiz Perez, LM; da Souza, W; Kaiser, M; Brun, R; Urbina, JA; Gonzalez Pacanowska, D; Gilbert, IH Quinuclidine derivatives as potential antiparasitics. Antimicrob Agents Chemother51:4049-61 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Squalene synthase

Name:

Squalene synthase

Synonyms:

Farnesyltransferase, putative

Type:

PROTEIN

Mol. Mass.:

47117.40

Organism:

Leishmania major

Description:

ChEMBL_520603

Residue:

414

Sequence:

MGFFSDSVAMMRVKWQMRSVKIQVPPEETDLRFCYDIMNDVSRSFAVVVAQLADQQLRDA
ICIFYLVLRALDTLEDDMSVPVDVKLKELPKFHTHTSDMSWCMSGVGEGRERELLAKYPC
VSREFKKLKKEYQDVIANICERMANGMCEFLKRPVVTKDDYNQYCHYVAGLVGHGLTQLF
ARCGFEDPSLDDDLTSSNHMGLFLQKTNIIRDYYEDIREEPPRMFWPKEIWGTYVTELKE
LKSESNNAAAVQCLNAMVADALVHVPYIVDYLSALRDPSVFRFCAIPQVMAIATLKEVYN
NPDTFQVKVKVSRPESCRIMLKATTLYSSLSMFRDYCVELQEKLDMQDASSVSIANSLAA
AIERIDLQLKKCQDVSYTRSLLARYPGLGGQFLLTVMDTVAGFFGGRKEIAGHA

BDBM50270322

n/a

Name

BDBM50270322

Synonyms:

3-(2'-Naphtyl)-quinuclidine-2-ene | CHEMBL516895

Type

Small organic molecule

Emp. Form.

C17H17N

Mol. Mass.

235.3236

SMILES

C1CN2CCC1C(=C2)c1ccc2ccccc2c1 |c:7,(7.97,-11.66,;7.97,-13.21,;9.31,-13.97,;10.06,-12.64,;8.57,-12.24,;9.31,-10.88,;10.65,-11.66,;10.65,-13.21,;11.98,-10.89,;13.31,-11.66,;14.64,-10.9,;14.64,-9.36,;15.98,-8.58,;15.97,-7.04,;14.63,-6.27,;13.3,-7.05,;13.3,-8.59,;11.98,-9.36,)|

Structure