Reaction Details |
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Target | Proteinase-activated receptor 1 |
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Ligand | BDBM50260519 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_556010 (CHEMBL964660) |
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Ki | 11±n/a nM |
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Citation | Chackalamannil, S; Wang, Y; Greenlee, WJ; Hu, Z; Xia, Y; Ahn, HS; Boykow, G; Hsieh, Y; Palamanda, J; Agans-Fantuzzi, J; Kurowski, S; Graziano, M; Chintala, M Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity. J Med Chem51:3061-4 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Proteinase-activated receptor 1 |
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Name: | Proteinase-activated receptor 1 |
Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
Type: | Protein |
Mol. Mass.: | 47450.07 |
Organism: | Homo sapiens (Human) |
Description: | P25116 |
Residue: | 425 |
Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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BDBM50260519 |
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n/a |
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Name | BDBM50260519 |
Synonyms: | CHEMBL521531 | ethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-chlorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxo-dodecahydronaphtho[2,3-c]furan-6-ylcarbamate |
Type | Small organic molecule |
Emp. Form. | C29H33ClN2O4 |
Mol. Mass. | 509.036 |
SMILES | CCOC(=O)N[C@@H]1CC[C@@H]2[C@H](C[C@@H]3[C@@H]([C@@H](C)OC3=O)[C@H]2C=Cc2ccc(cn2)-c2cccc(Cl)c2)C1 |r,w:21.23| |
Structure |
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