| Reaction Details |
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 | Report a problem with these data |
| Target | Phenylethanolamine N-methyltransferase |
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| Ligand | BDBM50240934 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_553549 (CHEMBL958732) |
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| IC50 | 28±n/a nM |
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| Citation |  Congreve, M; Chessari, G; Tisi, D; Woodhead, AJ Recent developments in fragment-based drug discovery. J Med Chem51:3661-80 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phenylethanolamine N-methyltransferase |
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| Name: | Phenylethanolamine N-methyltransferase |
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| Synonyms: | Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT) |
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| Type: | Enzyme |
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| Mol. Mass.: | 30852.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 282 |
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| Sequence: | MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
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| BDBM50240934 |
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| n/a |
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| Name | BDBM50240934 |
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| Synonyms: | 3-(hydroxymethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | 3-Hydroxymethyl-1,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid (3,3,3-trifluoro-propyl)-amide | CHEMBL175519 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H17F3N2O3S |
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| Mol. Mass. | 338.346 |
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| SMILES | OCC1Cc2ccc(cc2CN1)S(=O)(=O)NCCC(F)(F)F |
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| Structure | 
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