| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit rho-1 |
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| Ligand | BDBM50243875 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_554600 (CHEMBL964514) |
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| IC50 | >100000±n/a nM |
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| Citation |  Kumar, RJ; Chebib, M; Hibbs, DE; Kim, HL; Johnston, GA; Salam, NK; Hanrahan, JR Novel gamma-aminobutyric acid rho1 receptor antagonists; synthesis, pharmacological activity and structure-activity relationships. J Med Chem51:3825-40 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit rho-1 |
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| Name: | Gamma-aminobutyric acid receptor subunit rho-1 |
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| Synonyms: | GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55892.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456653 |
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| Residue: | 479 |
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| Sequence: | MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI
LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM
TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV
QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD
ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW
VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL
EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP
DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
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| BDBM50243875 |
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| n/a |
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| Name | BDBM50243875 |
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| Synonyms: | CHEMBL451118 | cis-3-Amino-cyclobutyl(methyl)phosphinic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C5H12NO2P |
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| Mol. Mass. | 149.128 |
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| SMILES | CP(O)(O)C1=C[C@@H](N)C1 |r,t:4| |
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| Structure | 
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