BindingDB PrimarySearch

Found 18 hits Enz. Inhib. hit(s) with all data for entry = 50026285
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50032973 (((Z)-3-Amino-propenyl)-methyl-phosphinic acid \| 3-...) Show SMILES CP(O)(=O)CCC=N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50240386 (5-amino-4-oxopentanoic acid \| 5-aminolevulinic aci...) Show SMILES NCC(=O)CCC(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.29E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50032982 ((3-Amino-propyl)-butyl-phosphinic acid \| 3-aminopr...) Show SMILES CCCCP(O)(=O)CCCN Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50243875 (CHEMBL451118 \| cis-3-Amino-cyclobutyl(methyl)phosp...) Show SMILES CP(O)(O)C1=C[C@@H](N)C1 \|r,t:4\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50243876 (CHEMBL447036 \| trans-3-Amino-cyclobutyl(methyl)pho...) Show SMILES CP(O)(O)C1=C[C@H](N)C1 \|r,t:4\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50241194 ((1S,2R)-2-(aminomethyl)cyclopropanecarboxylic acid...) Show SMILES NC[C@@H]1C[C@@H]1C(O)=O \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM23183 (5-(aminomethyl)-1,2-oxazol-3-ol \| Agarin \| CHEMBL2...) Show SMILES NCc1cc(=O)[nH]o1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50243927 ((1S,2S)-2-(aminomethyl)cyclopropanecarboxylic acid...) Show SMILES NC[C@H]1C[C@@H]1C(O)=O \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50243926 ((1R,2R)-2-(aminomethyl)cyclopropanecarboxylic acid...) Show SMILES NC[C@@H]1C[C@H]1C(O)=O \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM24183 (4-amino-n-[2,3-3H]butyric acid \| 4-aminobutanoic a...) Show SMILES NCCCC(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid type B receptor subunit 1 (Homo sapiens (Human))	BDBM24183 (4-amino-n-[2,3-3H]butyric acid \| 4-aminobutanoic a...) Show SMILES NCCCC(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50087271 ((E)-4-Amino-but-2-enoic acid (TACA) \| 4-Amino-but-...) Show SMILES NC\C=C\C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	400	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Homo sapiens (Human))	BDBM50243873 ((-)-(R)-4-Amino-1-cyclopent-1-enyl(methyl)phosphin...) Show SMILES CP(O)(=O)C1=CC[C@@H](N)C1 \|r,t:4\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.19E+4	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Homo sapiens (Human))	BDBM50243872 ((+/-)-4-Amino-1-cyclopent-1-enyl(methyl)phosphinic...) Show SMILES CP(O)(=O)C1=CCC(N)C1 \|t:4\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Homo sapiens (Human))	BDBM50211642 (CHEMBL397209 \| Methyl(1,2,3,6-tetrahydropyridinium...) Show SMILES CP(O)(=O)C1=CCNCC1 \|t:4\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	5.00E+5	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50087277 ((Z)-4-Amino-but-2-enoic acid \| (Z)-4-aminobut-2-en...) Show SMILES NC\C=C/C(O)=O Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.40E+4	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit rho-1 (Homo sapiens (Human))	BDBM50243877 ((1R,2S)-2-(aminomethyl)cyclopropanecarboxylic acid...) Show SMILES NC[C@H]1C[C@H]1C(O)=O \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid type B receptor subunit 1 (Homo sapiens (Human))	BDBM50243874 ((+)-(S)-4-Amino-1-cyclopent-1-enyl(methyl)phosphin...) Show SMILES CP(O)(=O)C1=CC[C@H](N)C1 \|r,t:4\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.22E+4	n/a	n/a	n/a	n/a
University of Sydney Curated by ChEMBL					Assay Description Agonist activity at human GABAb 1A/2 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp m...				J Med Chem 51: 3825-40 (2008) Article DOI: 10.1021/jm7015842 BindingDB Entry DOI: 10.7270/Q27M07RR
University of Sydney Curated by ChEMBL					More data for this Ligand-Target Pair