| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2-associated protein 1 |
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| Ligand | BDBM50243046 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491562 (CHEMBL944208) |
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| IC50 | 3700±n/a nM |
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| Citation |  Janetka, JW; Almeida, L; Ashwell, S; Brassil, PJ; Daly, K; Deng, C; Gero, T; Glynn, RE; Horn, CL; Ioannidis, S; Lyne, P; Newcombe, NJ; Oza, VB; Pass, M; Springer, SK; Su, M; Toader, D; Vasbinder, MM; Yu, D; Yu, Y; Zabludoff, SD Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors. Bioorg Med Chem Lett18:4242-8 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2-associated protein 1 |
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| Name: | Cyclin-dependent kinase 2-associated protein 1 |
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| Synonyms: | CDK2AP1 | CDKA1_HUMAN | CDKAP1 | DOC1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 12370.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_491562 |
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| Residue: | 115 |
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| Sequence: | MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQ
SKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS
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| BDBM50243046 |
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| n/a |
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| Name | BDBM50243046 |
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| Synonyms: | (S)-1-(5-(4-chlorophenyl)-3-(piperidin-3-ylcarbamoyl)thiophen-2-yl)urea | 2-(carbamoylamino)-5-(4-chlorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-3-carboxamide | CHEMBL470288 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19ClN4O2S |
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| Mol. Mass. | 378.876 |
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| SMILES | NC(=O)Nc1sc(cc1C(=O)N[C@H]1CCCNC1)-c1ccc(Cl)cc1 |r| |
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| Structure | 
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