| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease falcipain-3 [5-492] |
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| Ligand | BDBM50243177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_491631 (CHEMBL945402) |
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| IC50 | >25000±n/a nM |
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| Citation |  Verissimo, E; Berry, N; Gibbons, P; Cristiano, ML; Rosenthal, PJ; Gut, J; Ward, SA; O'Neill, PM Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. Bioorg Med Chem Lett18:4210-4 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease falcipain-3 [5-492] |
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| Name: | Cysteine protease falcipain-3 [5-492] |
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| Synonyms: | Cysteine protease falcipain-3 | Q9NAW4_PLAFA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56106.86 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_430127 |
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| Residue: | 488 |
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| Sequence: | MEYSPNEVIKQEREVFVGKEKSGSKFKRKRSIFIVLTVSICFMFALMLFYFTRNENNKTL
FTNSLSNNINDDYIINSLLKSESGKKFIVSKLEELISSYDKEKKMRTTGAEENNMNMNGI
DDKDNKSVSFVNKKNGNLKVNNNNQVSYSNLFDTKFLMDNLETVNLFYIFLKENNKKYET
SEEMQKRFIIFSENYRKIELHNKKTNSLYKRGMNKFGDLSPEEFRSKYLNLKTHGPFKTL
SPPVSYEANYEDVIKKYKPADAKLDRIAYDWRLHGGVTPVKDQALCGSCWAFSSVGSVES
QYAIRKKALFLFSEQELVDCSVKNNGCYGGYITNAFDDMIDLGGLCSQDDYPYVSNLPET
CNLKRCNERYTIKSYVSIPDDKFKEALRYLGPISISIAASDDFAFYRGGFYDGECGAAPN
HAVILVGYGMKDIYNEDTGRMEKFYYYIIKNSWGSDWGEGGYINLETDENGYKKTCSIGT
EAYVPLLE
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| BDBM50243177 |
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| n/a |
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| Name | BDBM50243177 |
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| Synonyms: | (S)-benzyl 2-oxo-1-(1-oxo-4-phenylbutan-2-yl)-1,2-dihydropyridin-3-ylcarbamate | CHEMBL488829 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22N2O4 |
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| Mol. Mass. | 390.4318 |
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| SMILES | O=C[C@H](CCc1ccccc1)n1cccc(NC(=O)OCc2ccccc2)c1=O |r| |
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| Structure | 
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