Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50252018 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_487516 (CHEMBL1012268) |
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IC50 | 7100±n/a nM |
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Citation | Middleton, DS; Andrews, M; Glossop, P; Gymer, G; Hepworth, D; Jessiman, A; Johnson, PS; Mackenny, M; Pitcher, MJ; Rooker, T; Stobie, A; Tang, K; Morgan, P Designing rapid onset selective serotonin re-uptake inhibitors. 2: structure-activity relationships of substituted (aryl)benzylamines. Bioorg Med Chem Lett18:4018-21 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68497.11 |
Organism: | Homo sapiens (Human) |
Description: | Q01959 |
Residue: | 620 |
Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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BDBM50252018 |
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n/a |
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Name | BDBM50252018 |
Synonyms: | (5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dimethylmethanamine | 1-(5-fluoro-2-(4-(methylthio)phenoxy)phenyl)-N,N-dimethylmethanamine | CHEMBL446481 |
Type | Small organic molecule |
Emp. Form. | C16H18FNOS |
Mol. Mass. | 291.384 |
SMILES | CSc1ccc(Oc2ccc(F)cc2CN(C)C)cc1 |
Structure |
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